What We Do
Research
Research Areas
01
Somatic Mosaicism
We study somatic mutations that accumulate during cell division, tracing their origins through mutational signature and lineage analysis across diverse tissue types.
🧠
Brain
Finding cellular origin of hypermutable brain tissues.
🫁
Lung
Exploring hidden genetic causes in congenital lung disease.
🔬
Urine
Monitoring kidney transplant patients.
02
Multi-Omics
Integrating genomic, transcriptomic, epigenomic, and proteomic data to functionally interpret somatic mutations and their impact on disease.
Developmental Senescence
Investigating cellular aging mechanisms during early development.
Parkinson's Disease
Uncovering somatic mutation contributions to neurodegeneration.
03
Bio-AI
Leveraging foundation models and deep learning to predict variant effects, design therapeutics, and build prognostic tools.
| Model | Application |
|---|---|
| Single Cell FM | Prognostic prediction for transplant recipients using scFM |
| Genomic FM | Variant effect prediction |
| Structure Prediction | New druggable peptide design |