MOsAIciSM
Decoding Somatic Mosaicism
with AI and Multi-Omics
31
Publications
3
Research Areas
2024
Established
31
Publications
3
Research Areas
2024
Established
About Our Lab
We study how somatic mutations shape human development, aging, and disease — by combining large-scale genomic analysis, multi-omics integration, and AI-driven models.
Our lab specializes in somatic mosaicism — the phenomenon where individual cell populations accumulate unique mutations during cell division, forming distinct genomic patterns. We develop experimental and computational methodologies to detect somatic mosaicism from single-cell and whole-genome sequencing data.
Through mutational signature and lineage analysis, we trace the origins of these variations and explore early human developmental processes that are experimentally challenging to study. By integrating diverse multi-omic datasets, we perform functional interpretation of somatic mutations and investigate their impact on human development, aging, and their associations with various diseases.
Korea University
School of Biosystems and Biomedical Sciences
Keywords
Research Areas
Somatic Mosaicism
Detecting somatic mutations in brain, lung, and urine with single-cell and ultra-high-resolution WGS.
Multi-Omics
Integrating diverse multi-omic datasets to study developmental senescence and Parkinson's disease.
Bio-AI
Foundation models for single-cell, genomic variant prediction, and druggable peptide design.